Cancer Biology ⁽⁴⁾

All living things are constantly evolving, and the various cells of living things are evolving too; the essence of evolution is change in a life form's adaptability to the environment. Cancer cells are no exception. Although evolutionary reversal does occur, just as humans cannot revert…

In the past, the consensus in cancer biology was that activation of proto-oncogenes and inactivation of tumor suppressor genes cause carcinogenesis. But recent studies show that, besides proto-oncogenes and tumor suppressor genes, another gene also plays an important role in the occurrence and development of…

Lynch syndrome is a common autosomal dominant genetic disease resulting from germline mutations in DNA mismatch repair genes; it is also called HNPCC syndrome. The lifetime risk of colon cancer in Lynch patients is about 70–80%, and Lynch syndrome accounts for 2–4% of all colorectal…

Li-Fraumeni syndrome (LFS) is a familial genetic disease with an incidence in the general population as high as 1 in 20,000. It is inherited in an autosomal dominant manner, and the mutated gene is TP53, located at chromosome 17p13. Li-Fraumeni syndrome is one of the…